venofer dosing calculator

1995 Mar-Apr;11(2):163-8. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. commonly, these are generic drugs. LBW = Lean body weight in kg. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Applies only to oral form of both agents. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). The elemental iron product used is Iron sucrose 20 mg/mL. Do not administer Venofer to patients with evidence of iron overload. Minor/Significance Unknown. Applies only to oral form of both agents. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. 1990 Feb;24(2):162-6. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Either decreases levels of the other by inhibition of GI absorption. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Venofer has not been studied in patients younger than 2 years old. May increase risk of hypotension. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Iron sucrose: 20 mg/mL. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). *Repeat dose if iron deficiency anemia reoccurs. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. Minor/Significance Unknown. J Med. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Can't find what you need? Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. I. iron sucrose, benazepril. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Discuss the risks and benefits with your doctor.This medication passes into breast milk. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Avoid or Use Alternate Drug. Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. Use Caution/Monitor. Reactions have occurred following the first dose or subsequent doses of Venofer. Minor/Significance Unknown. 2010; 193(9):525-32. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). iron sucrose increases levels of calcium acetate by enhancing GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Modify Therapy/Monitor Closely. Copyright 1993-2021 commonly, these are "preferred" (on formulary) brand drugs. Information last revised December 2022. We comply with the HONcode standard for trustworthy health information. Use alternatives if available. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Either increases effects of the other by pharmacodynamic synergism. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). 1988 May;111(5):566-70. The recipient will receive more details and instructions to access this offer. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Avoid or Use Alternate Drug. iron sucrose increases levels of calcium chloride by enhancing GI absorption. You will have to pay for your IV iron. For liquid medications, also enter the value of the Medicine Concentration and choose . Pregnancy: Risk Summary-Clinical Considerations. Anemia; 2015: 763576. Applies only to oral form of both agents. Use Caution/Monitor. 2000 Jan;22(1):39-43. The iron formulation choice remains for the clinician to make. MISSED DOSE: It is important to get each dose of this medication as scheduled. Medically reviewed by Drugs.com. Separate dosing of tetracyclines from these products. Use Caution/Monitor. ]Venofer treatment may be repeated if iron deficiency reoccurs. Minor/Significance Unknown. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Each mL contains 20 mg of elemental iron. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. This document does not contain all possible drug interactions. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Baloxavir may bind to polyvalent cations resulting in decreased absorption. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Applies only to oral form of both agents. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. 2. The dosage of Venofer is expressed in mg of elemental iron. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. There is in depth information below the form on the method used and on the result provided. Schweiz Med Wochenschr; 100(7):301-3. For additional Safety Information, please see Full Prescribing Information. Consult your pharmacist or local waste disposal company. Applies only to oral form of both agents. Venofer treatment may be repeated if necessary. Applies only to oral form of both agents. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Minor/Significance Unknown. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Separate by 2 hr. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Corrected Sodium and Effective Osmolality. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Applies only to oral form of both agents. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. . Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Use Caution/Monitor. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. https://www.uptodate.com/ (Requires subscription). Found in multiple references. Use Caution/Monitor. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Burns DL, Mascioli EA, Bistrian BR. Ganzoni AM. Pain, swelling, or redness at the injection site may occur. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. These can be input in g/dL, g/L or mmol/L. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Most Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Test Dose: Not required. 1) Ganzoni AM. Last updated on Jun 1, 2022. Applies only to oral form of both agents. J Lab Clin Med; 111(5):566-70. Applies only to oral form of both agents. Interaction only with oral iron administration. Ren Fail. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). No additional iron to replenish stores. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. This drug is available at the lowest co-pay. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Separate by at least 4 hours. Where C= concentration of Applies only to oral form of both agents. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Anemia. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator 1 Dosing for patients who weigh less than 50 kg Most When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. 2012;2(4):288-335. 2.1 . Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. Administer Venofer only intravenously by slow injection or by infusion. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Intravenous iron sucrose: establishing a safe dose. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Use Caution/Monitor. Use Caution/Monitor. This website also contains material copyrighted by 3rd parties. Each mL contains 20 mg of elemental . Use Caution/Monitor. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Available for Android and iOS devices. Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Applies only to oral form of both agents. Administer a test INFeD dose prior to the first therapeutic dose. Dosing: (a) Divide calculated total cumulate dose . Use Caution/Monitor. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility .

John Cena Wipeout Salary, Def Leppard Drummer Death, Articles V